NeurologyGeneralized, AChR-positive (Biologic-Treated)

Your patients' symptoms change by the hour. Your data collection doesn't.

Myasthenia gravis is defined by fluctuation — weakness that worsens with activity, improves with rest, and shifts unpredictably across muscle groups throughout the day. Clinic visits capture a single snapshot. Forma captures the full picture.

The challenge

Why traditional data collection fails for Myasthenia Gravis

MG-ADL scores at quarterly visits tell you where a patient was at 10am on a Tuesday. They don't tell you about the choking episode at dinner, the arms that gave out folding laundry, or the night spent propped on three pillows unable to breathe lying flat. Between visits, the disease fluctuates without a record — and the most clinically meaningful moments happen when no one is measuring.

The approach

Capture data the way patients experience their condition

Forma turns each patient into a continuous data stream. By voice or text, patients log what's happening in the moment — fatigable weakness, bulbar safety events, infusion responses, breathing changes — in 20 seconds. No forms, no recall bias. The result is structured, longitudinal data across every MG domain, paired with the clinical assessments you already collect.

Meet the patients in this demo

S

Sarah, 34

Generalized MG, on Vyvgart infusion cycles. Works part-time from home. Bulbar and limb-predominant symptoms.

F

Frank, 67

Late-onset MG, on azathioprine and prednisone with IVIg for flares. History of myasthenic crisis. Wife helps log.

11 topics configured for this study

How it works

From patient voice to structured data

Patients log what's happening in their own words — by voice or text. Forma structures every observation into research-ready data automatically.

S
SarahMuscle Weakness

My arms gave out folding laundry after about 8 minutes. Had to sit down and rest before I could finish. Definitely worse later in the day.

Structured output
Topic: Muscle Weakness
Body Region: Arms — proximal
Severity: Gave out after 8 min
Time Pattern: Worse later in day
Rest Recovery: Improved after sitting
Functional Impact: Unable to complete laundry
F
FrankBulbar Function

Couldn't finish my sandwich — jaw gave out halfway through. Had to eat yogurt for lunch instead.

Structured output
Topic: Bulbar Function
Domain: Chewing
Severity: 2 / 3
Functional Impact: Diet modification required
Safety Concern: None reported
S
SarahRespiratory Function

I can only get a few words out before I have to stop to breathe. This is much worse than last week.

Structured output
Topic: Respiratory Function
Breathing Difficulty: 3 / 3 — at rest
Speech Impact: Single words only
Trend: Worsening vs. last week
Crisis Flag: ⚠ Potential crisis indicator
S
SarahInfusion / Treatment Session

Had my Vyvgart infusion today — this is week 2 of 4 in my current cycle. The infusion took about an hour. No reactions this time.

Structured output
Topic: Infusion / Treatment Session
Treatment: Vyvgart (efgartigimod IV)
Cycle Position: Week 2 of 4
Duration: ~1 hour
Reaction: None
F
FrankMG Functional Assessment

Bad day. Speech is a 3 — people can't understand me. Swallowing is a 2, chewing is a 2. Breathing is a 1. Arms are a 2, can't get up without pushing — score 2. Both eyelids drooping — score 2. Diplopia every day but not constant — score 2.

Structured output
Topic: MG Functional Assessment
MG-ADL Total: 16 / 24
Speech: 3 — unintelligible
Swallowing: 2 — severe
Ptosis: 2 — bilateral
Diplopia: 2 — daily

The insight

What continuous data reveals

Individual observations compound into a longitudinal picture that clinic visits alone cannot provide. Here's what one treatment cycle looks like through daily patient logs.

Mon, Mar 3Day 1

Arms gave out folding laundry. Eyelid droop starting in the evening. Speech slightly nasal.

Arms 2Speech 1Swallowing 0Ptosis 1Breathing 0
Tue, Mar 4Day 2
Choking episode flagged

Choked on water at dinner. Switched to thickened liquids. Double vision in the evening.

Arms 1Speech 1Swallowing 2Ptosis 1Breathing 0
Wed, Mar 5Day 3

Fatigue hit hard — cancelled plans, two naps. Swallowing back to normal.

Arms 2Speech 1Swallowing 1Ptosis 1Breathing 0
Thu, Mar 6Day 4
💉Vyvgart infusion — Week 1 of 4

Week 1 Vyvgart infusion. Mild headache after — 3/10. Otherwise fine.

Arms 2Speech 1Swallowing 1Ptosis 1Breathing 0
Fri, Mar 7Day 5

Slightly better after infusion. Managed to work 3 hours. Eyelid droop only after reading.

Arms 1Speech 1Swallowing 1Ptosis 1Breathing 0
Sun, Mar 9Day 7
💊Mestinon side effect — muscle cramps

Good day — ate a normal dinner, no choking. Mestinon causing some cramping.

Arms 1Speech 0Swallowing 0Ptosis 1Breathing 0
Thu, Mar 13Day 11
💉Vyvgart infusion — Week 2 of 4

Week 2 Vyvgart infusion. No reactions. Already feeling noticeably stronger.

Arms 1Speech 1Swallowing 0Ptosis 1Breathing 0
Sun, Mar 16Day 14
Marked improvement across all domains

Best day in weeks. Folded laundry, did dishes, styled hair without stopping. No choking at all.

Arms 0Speech 0Swallowing 0Ptosis 0Breathing 0
Thu, Mar 20Day 18
💉Vyvgart infusion — Week 3 of 4

Week 3 — usually the best week. Speech clear, swallowing normal, arms strong.

Arms 0Speech 0Swallowing 0Ptosis 0Breathing 0
Mon, Mar 24Day 22

Starting to feel the cycle wearing off. Arms slightly weaker, eyelid droop returning.

Arms 1Speech 0Swallowing 0Ptosis 1Breathing 0
Thu, Mar 27Day 25
💉Vyvgart infusion — Week 4 of 4 (cycle complete)

Final week 4 infusion. Cycle complete. Bulbar symptoms have improved dramatically over the month.

Arms 1Speech 0Swallowing 0Ptosis 1Breathing 0

Key insight

Over one Vyvgart cycle, Sarah's daily logs reveal what clinic visits cannot: arms improving from score 2 to 0 by week 3, a choking episode on day 2 that triggered a safety flag, and the visible correlation between infusion timing and functional recovery. This is the data that turns a quarterly MG-ADL score into a continuous treatment response curve.

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