Postural Orthostatic Tachycardia Syndrome (POTS)
Voice-first health observation platform for POTS, capturing orthostatic vitals, symptom severity, brain fog, fatigue, hydration, exercise tolerance, and autonomic dysfunction patterns through natural language.
Study Overview
About this study
POTS affects an estimated 1–3 million Americans, with incidence surging post-COVID-19, yet no FDA-approved therapy exists and no validated POTS-specific patient-reported outcome measure has been developed. The condition's defining feature — dramatic hour-to-hour and day-to-day symptom variability driven by hydration, sleep, heat exposure, menstrual phase, and medication timing — is completely invisible to periodic clinic assessments. Forma captures structured daily observations across all six POTS clinical domains (cardiovascular/orthostatic, neurological/cognitive, fatigue/post-exertional, gastrointestinal, thermoregulatory, and sleep/autonomic), producing longitudinal datasets suitable for both individual patient management and real-world evidence generation to support therapeutic development.
What's included
Key features
- Voice-first orthostatic symptom logging with lying and standing heart rate capture
- Fluid intake and sodium supplementation tracking against daily targets
- Brain fog episode documentation with cognitive impact and trigger identification
- Graduated exercise program monitoring with post-exertional crash tracking
- Thermoregulatory and vasomotor symptom capture including blood pooling and flushing
- Medication response tracking across off-label POTS pharmacotherapy
- Menstrual cycle correlation with POTS symptom flare patterns
Topic Configuration
Configured topics
Each study includes pre-configured topics that patients interact with daily. Here are examples of how we've set up data collection for this study.
Orthostatic Symptoms
Sample questions
- What position triggered the symptoms?
- What was your heart rate lying down vs standing?
- How severe was the episode?
- What symptoms did you experience?
- How did you recover?
Brain Fog & Cognition
Sample questions
- How severe is the brain fog?
- What cognitive symptoms are you experiencing?
- How is it impacting your day?
- What do you think triggered it?
Hydration
Sample questions
- How much fluid did you drink today?
- How much sodium did you consume?
- What types of fluids did you have?
- Did you meet your intake goal?
Exercise & Activity
Sample questions
- What type of activity did you do?
- How long did it last?
- What was your body position during the activity?
- Did you experience a post-exertional crash?
Thermoregulation & Vasomotor
Sample questions
- What type of thermoregulatory symptom?
- What triggered it?
- How severe was it?
- How did it impact your activity?
Ready to see Postural Orthostatic Tachycardia Syndrome (POTS) in action?
Book a demo and we'll walk you through this study configuration live.